Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus
نویسندگان
چکیده
منابع مشابه
Structural characterization of the 1918 influenza virus H1N1 neuraminidase.
Influenza virus neuraminidase (NA) plays a crucial role in facilitating the spread of newly synthesized virus in the host and is an important target for controlling disease progression. The NA crystal structure from the 1918 "Spanish flu" (A/Brevig Mission/1/18 H1N1) and that of its complex with zanamivir (Relenza) at 1.65-A and 1.45-A resolutions, respectively, corroborated the successful expr...
متن کاملMolecular Characterization and Phylogenetic Analysis of Neuraminidase Gene in A/H1N1 Influenza Virus Isolates Circulating in Iran, 2014-2015.
Objectives: Influenza is one of the most important emerging and reemerging infectious diseases in the world. The aim of this study is molecular and phylogenetic analyses of the variations in circulating influenza A/H1N1 virus isolates during 2014-2015 in Iran and investigate on the drug resistance conditions in the related Iranian isolates. Material and Methods: Throat samples from Iranian pat...
متن کاملThe N-terminal domain of PA from bat-derived influenza-like virus H17N10 has endonuclease activity.
Influenza imposes a great burden on society, not only in its seasonal appearance that affects both humans and domesticated animals but also through the constant threat of potential pandemics. Migratory birds are considered to be the reservoir hosts for influenza viruses, but other animals must also be considered. The recently identified influenza-like virus genome, from H17N10 in bats, was show...
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A(H1N1)pdm09 influenza A viruses predominated in the 2013-2014 USA influenza season, and although most of these viruses remain sensitive to Food and Drug Administration-approved neuraminidase (NA) inhibitors, alternative therapies are needed. Here we show that monoclonal antibody CD6, selected for binding to the NA of the prototypic A(H1N1)pdm09 virus, A/California/07/2009, protects mice agains...
متن کاملThe NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone.
Influenza A viruses have the potential to cause pandemics due to the introduction of novel subtypes against which human hosts have little or no preexisting immunity. Such viruses may result from reassortment between human and animal influenza viruses. Recently, new influenza-like viruses were identified in bats, raising the concern for a new reservoir of potentially harmful influenza viruses th...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1211037109